Towards integrated analysis of longitudinal whole-body small animal imaging studies

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Lelieveldt, B.P.F.  Botha, C.P.  Kaijzel, E.L.  Hendriks, E.A.  Reiber, J.H.C.  Lowik, C.W.G.M.  Dijkstra, J. 
Dept. of Radiol., Leiden Univ. Med. Center, Leiden, Netherlands 

This paper appears in: Acoustics, Speech and Signal Processing (ICASSP), 2011 IEEE International Conference on
Issue Date: 22-27 May 2011
On page(s): 5768 - 5771
Location: Prague
ISSN: 1520-6149
E-ISBN: 978-1-4577-0537-3
Print ISBN: 978-1-4577-0538-0
INSPEC Accession Number: 12176459
Digital Object Identifier: 10.1109/ICASSP.2011.5947671
Date of Current Version: 12 July 2011


This paper discusses a number of image analysis challenges emerging from longitudinal small animal molecular imaging studies. Three steps towards a quantitative 3D analysis of follow-up small animal imaging are presented: whole-body articulated registration, change visualization in follow-up data and fusion of optical and 3D structural imaging data. Several application examples are presented in the context of translational cancer research.

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